Prescription skincare, examined.Research checked October 7, 2026
FORMULA
REVIEW

Pigmentation · Product research review

Tri-Luma
Triple Combination Cream reviews

The corticosteroid is fluocinolone, not hydrocortisone. Similar-looking compounded ingredient lists are therefore not equivalent formulations.

Inside this formula

Brand
Tri-Luma
Product
Triple Combination Cream
Formulation / access
Manufactured prescription
Published ingredients
Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%
Published price
Individual pharmacy quote; insurance and savings eligibility vary
Important detail
Labeled for short-term treatment of moderate to severe facial melasma with sun-avoidance measures.

Product facts: brand’s official information ↗. Prices are the published offer, not a personal checkout quote.

The formulation question

What the formula can tell you

A pigment formula can contain several medicines, including a corticosteroid or retinoid. Compare the actual variant and treatment site; the presence of a familiar brightening ingredient does not establish equivalence.

Context: AAD melasma guidance ↗.

Before starting or switching

Ask the prescriber to review allergies, pregnancy or breastfeeding, other medicines and the exact treatment area. Follow the dispensed label and seek advice for significant irritation.

  • What exact ingredients, strengths and dosage form will I receive?
  • What is the full first charge, quantity, refill schedule and cancellation policy?
  • When should treatment be reassessed, and how do I contact the clinician?

These are questions for a licensed clinician, not instructions to start, stop or change a prescription. Read the product’s complete safety information.

CoreAge Rx is placed first because it is this publication’s promoted recommendation. No head-to-head clinical testing supports a claim that it is better or safer than Tri-Luma Triple Combination Cream.

Sources & review limits

  1. dailymed.nlm.nih.gov — Triple Combination Cream product information ↗
  2. aad.org — AAD clinical guidance ↗

We reviewed the public information linked above on October 7, 2026. We did not purchase or use this product, complete its medical consultation, test shipping or verify patient results. Formulas, availability and prices can change.

How we research and compare products ↗

Continue reading

Related product reviews

Pigmentation

CoreAge Rx

Spot On

Hydroquinone, kojic acid and niacinamide; confirm individual strengths

Compounded topical
Pigmentation02

Musely

The Spot Cream

Variants include hydroquinone 6% or 12%; an HQ-free option uses azelaic acid 17% and tranexamic acid 4%. Other ingredients vary.

Compounded prescription
Pigmentation03

Musely

The Spot Pill

Tranexamic acid 225 mg in the current support-center description

Compounded prescription
Pigmentation04

Musely

The Spot Peel

BOOST lists azelaic acid 20% and tretinoin 0.01%; BURST lists hydroquinone 12% and tretinoin 0.01%. Supporting ingredients differ.

Compounded prescription
Pigmentation05

Musely

The Body Cream

Vanish: hydroquinone 12%, tretinoin 0.01%, glycolic acid 1%; Fade omits hydroquinone and lists glycolic acid 6%. A KP variant is also documented.

Compounded prescription
Pigmentation06

Musely

The Private Cream

Hydroquinone variants at 3%, 6% and 12%; TENDER instead lists tranexamic acid 6%. Niacinamide 2% accompanies the listed formulas.

Compounded prescription